Abstract Rad51 maintains genome integrity, whereas Rad52 1st marine division hoodie causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs).Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres.Genetic and physical analyses show that srr1 and skb1 mutations reduce isochromosome
Mary P Nivison, Kathryn E Meier Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA Abstract: CCN proteins are secreted into the extracellular environment where they interact with both components of the extracellular matrix and with cell surface receptors to regulate
The May Fourth Movement (1917-1921) has always been an important part of the official historical narrative of the Chinese Communist Party.Today, the Movement is often celebrated as being closely connected with the emergence of modern Chinese patriotism and nationalism in contemporary China.In the 21st century, Chinese nationalism has voiced more as
Highlights It is widely recognized among hand surgeons that female patients present at a younger age for basal thumb osteoarthritis, with toyo proxes st iii 305/40r22 more severe degeneration.The little-known menstrual hormone relaxin, which peaks every ovulatory cycle, may be responsible for the female predominance of this pathology.The soft tissu
BackgroundToxoplasma gondii, an obligate intracellular protozoan, utilizes dense granule proteins to modulate host cell processes.Dense granule protein 23 (GRA23) facilitates molecular trafficking between the parasitophorous vacuole and host cell cyto-plasm, though its specific host protein interactions remain poorly characterized.MethodsThis study